Endocrine Abstracts

Background: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance, two major contributors to cardiovascular risk. Even in the absence of detectable insulin resistance, lean, non-diabetic PCOS women demonstrate increased circulating levels of advanced glycated end products (AGEs), known proatherogenic molecules. This adverse cardiovascular risk profile should be considered in the syndrome’s management.Objective: To invest...

Serum levels of soluble RAGE (sRAGE total), the soluble isoform of the receptor of advanced glycated end products (AGEs) that lacks the transmembrane and intracytoplasmic domains of RAGE, has been found elevated in type 2 diabetics and non diabetic subjects and positively correlated with AGEs levels. In women with PCOS, while serum AGEs have been demonstrated to be elevated, sRAGE levels have not been determined as yet.The aim of the present study was to...

Objective: Neuroinflammation is a common primary or secondary mediator of the neurodegenerative process accompanying Alzheimer’s disease (AD). Impaired brain insulin signaling, defining brain insulin resistance may represent a link between AD and type 2 diabetes mellitus (T2DM) while neuronal apoptosis may also be involved in the inflammatory process. Peripheral cytokine levels of IL-1β, IL-6, TNFα along with high sensitivity C-reactive protein (hsCRP) and apopt...